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Category Archives: HIV

Intergenerational Sex and Marriage: Just Another HIV Myth?


In 2007 the Population Council published an article on early marriage and HIV in Kenya. There’s nothing surprising about a eugenicist or ‘population’ NGO taking a close interest in such matters, of course, and the Population Reference Bureau published an article about cross-generational sex in various Africa countries in the same year. Both articles express concern about these phenomena potentially posing a risk for HIV transmission.

What is surprising is the figures used by the Population Council, listed below. The province where early marriage is most common, Northeastern, is the province where HIV prevalence is lowest, by a long shot. Early marriage is also less common in Nairobi, where HIV prevalence is second highest in the country. Where HIV prevalence is highest, Nyanza, early marriage is not particularly common. At least, there is no noticeable correlation between the phenomenon and HIV prevalence.

% married by 18 years HIV prev 08-09*
Northeastern 56 0.9
Eastern 16 3.5
Coast 34 4.2
Central 15 4.6
Rift Valley 35 4.7
Western 32 6.6
Nairobi 12 7
Nyanza 34 13.9

The relevant table is 14.5, page 217

In fact, these NGOs should have been very suspicious. HIV prevalence often tends to be higher among wealthier, better educated, urban dwelling, employed people, whereas intergenerational sex and marriage may be more closely associated with poorer, less well educated, rural dwelling, unemployed people.

So it is significant that AidsMap reported a presentation at the 21st Conference on Retroviruses and Opportunistic Infections (CROI). This presentation suggests that “Sex with older men is not placing women under 30 at higher risk of HIV infection in rural South Africa, and relationships with older men may even be protecting women over 30 from infection“.

The author of the study suggests that programs addressing relationships between older men and younger women may even stigmatize men and women in such relationships. But stigmatizing people with, or thought to be at risk of, HIV is something NGOs and international health institutions have never shied away from.

The media will be disappointed because they have enjoyed years of talking about sugar daddies and sugar mummies, which fits into the ‘all men are bastards, all women are victims’ paradigm of HIV transmission, and their concomitant assumptions that African men will do anything for sex and African women will do anything for money.

Many population (and eugenicist) NGOs generally also claim an interest in ‘reproductive health’, but their agenda often seems to veer towards matters that have little to do with health, and activities that have little to do with human rights. But for those that really are interested in health, there is another set of figures they may be interested in.

HIV prev 08-09 Medical supplies for common delivery complications
Northeastern 0.9 52
Eastern 3.5 61
Coast 4.2 59
Central 4.6 77
Rift Valley 4.7 49
Western 6.6 38
Nairobi 7 81
Nyanza 13.9 25

The Service Provision Assessment for Kenya for 2010 (Table 6.7, page 136) finds that only 25% of health facilities in Nyanza Province have essential supplies for common complications relating to child delivery, which means 75% of facilities lack “Needle and syringes, intravenous solution with infusion set, injectable oxytocic, and suture material and needle holder all located in delivery room area; oral antibiotic (cotrimoxazole or amoxicillin) located in pharmacy or delivery room area”.

With the highest HIV prevalence in Kenya, the fact that 46% of hospitals in Nyanza do not have all essential supplies for delivery, which refers to “Scissors or blade, cord clamp, suction apparatus, antibiotic eye ointment for newborn, skin disinfectant”, the Population Council and Population Reference Bureau may like to take a look at unsafe healthcare, now that intergenerational sex and marriage seem so much less of a priority now.

Again, these NGOs should also have noticed something important about HIV prevalence often being more closely associated with wealthier, better educated, employed, urban dwelling people: access to health facilities is also generally far higher among these groups. When poorer people with less education, those without formal employment and those who live in isolated rural areas do have access to health facilities, those facilities may turn out to be pretty unsafe. But that’s a matter for research that these NGOs haven’t yet carried out (or perhaps they just haven’t published it).

Ever-eager to snatch defeat from the jaws of victory, those who subscribe to the (eugenicist) population control theory of development in Africa, whether covertly or overtly, continue to receive generous funding. They don’t wish to lose any ground when it comes to pandering to the prejudices of those who still believe that Africans have loads of unsafe sex, and that this is why HIV prevalence is so much higher there. Yet, funding for unsafe healthcare always seems to put donors off their morning read, which is evidently when they set their funding priorities.

HIV Strategy: Blaming the Victim and their Individual Behavior


Since the early days of HIV/AIDS, finger pointing has been the main publicity angle. In Western countries the collective finger was pointed at men who have sex with men. Their reaction was to object to the finger being pointed at them and to insist that everyone is equally at risk. Though some still believe that everyone is equally at risk, it is not true. In Western countries the majority of HIV transmissions have always been among men who have sex with men, with a smaller proportion of transmissions through intravenous drug use.

But things are quite different in developing countries, particularly high HIV prevalence African countries. In high HIV prevalence countries men who have sex with men, intravenous drug users and even sex workers contribute a relatively small proportion of HIV transmissions. In fact, the largest contribution still appears to come from those with little or no risk; mainly monogamous heterosexuals. So the process of finger pointing often turns into one of victim blaming. After all, you can’t point the finger at everyone around you, nor at someone who is HIV negative; so the clearest ‘evidence’ of unsafe sexual behavior becomes HIV positive status.

This gives rise to the task of explaining how a virus that is difficult to transmit through heterosexual sex outside of Africa is so frequently transmitted through that route in Africa. The HIV industry needed to show that ‘Africans’ must be promiscuous, ignorant and unhygienic. This wasn’t too difficult because population control advocates (the word ‘eugenics’ is no longer fashionable), a significant proportion of wealthy NGOs operating in Africa, had had been playing the over-sexed, under-educated slum-dweller cards for decades.

The processes of pointing the finger at a particular group whose behavior was disapproved of, blaming those infected with HIV for their status, and concluding that HIV is all a matter of individual behavior, threw off course any efforts to reduce HIV transmission in developing countries. Although ‘prevention’ activities only receive a small proportion of HIV funding, that is still a massive amount of money. But prevention activities have rarely gone beyond exhortations to ‘behave’ in a particular way. The finger-wagging programs perfected by population control NGOs decades before HIV was identified became, and often remain, the state of the art of HIV prevention.

There has been plenty of research showing that these finger-wagging programs are of little or no benefit (except to the NGOs). An example of such research shows that “peer education programs in developing countries are moderately effective at improving behavioral outcomes, but show no significant impact on biological outcomes“. There is a voluminous body of literature showing that you can’t simply wag your finger at people and expect them to change their behavior, whether the aim is to address substance abuse, dangerous driving, over-eating or anything else.

Sometimes the association of HIV transmission with individual behavior is further connected with conditions that are beyond the control of the victim, for example, poverty. But this has also given rise to confusion: there is plenty of evidence that HIV in African countries is transmitted among wealthier people. This challenges the idea that HIV epidemics are driven by sexual behavior because, even if wealthy people ‘can afford to have a lot of sex and a lot of partners’, as the HIV industry would have it, there would need to be some poor people involved in this theory. Rich people don’t pay other rich people for sex.

Instead of looking beyond sex, or sex and poverty, it seems some researchers are convinced they will eventually find out how sex and economic inequalities ‘drive’ HIV epidemics. One paper concludes that “Further work is needed to understand the mechanisms explaining the concentration of HIV/AIDS among wealthier individuals and urban residents in [sub-Saharan Africa]“. But they don’t seem to consider the possibility that their protohypothesis about sex is simply wrong. They don’t seem to think that non-sexual transmission may be a very significant factor in the spread of HIV among wealthier people.

HIV can be transmitted through unsafe healthcare and other skin-piercing processes, such as various cosmetic processes. Wealthy people tend to have better access to healthcare. In fact, urban dwellers also tend to have better access to healthcare. Perhaps this is why the above paper found that HIV is “generally concentrated among wealthier men and women“. This may also explain why HIV “was concentrated among the poor in urban areas but among wealthier adults in rural areas” in a number of countries.

Instead of trying so hard (and failing, over and over again) to find out what it is about the sexual behavior of wealthy people and urban dwellers, perhaps researchers should look at non-sexual risks, as well as sexual risks. Could the risks that people face be determined by their wealth and environment, precisely because they are not sexual risks, but healthcare and other risks? These risks are clearly not *individual* risks. They relate to health-seeking behavior, but it is not the behavior of wealthy and/or urban-dwelling people that gives rise to infection with HIV in a hospital or salon; the risk of infection depends on whether the facility is safe or not (which might vary considerably over time).

Some historians of HIV, such as Jacques Pepin (The Origins of Aids), admit that HIV was mainly transmitted through unsafe healthcare for many decades, and hardly ever through sexual behavior. But they don’t explain how healthcare transmission magically disappeared in the 1980s even though conditions in many African countries remain very unsafe (although how unsafe they are is still a dangerously under-researched field).

Coupled with the magical disappearance of the risk of HIV transmission in under-equipped, under-staffed and badly run health facilities is the magical re-appearance of the promiscuous, ignorant and dirty African, though for many, this had never really gone away. Pepin vaguely mentions things like ‘urbanization’ as the main explanation for levels of promiscuity for which there has never been any evidence and which do not explain very high rates of heterosexual transmission of HIV anyway.

Ugandans have recently responded to having the finger pointed at them by allowing an ‘anti-homosexuality’ bill to be passed, effectively saying ‘it’s not us, it’s them’. Various human rights groups, and even some donors, may belatedly object to such disgusting measures, which are being copied by other African countries. But the objection needs to be directed at the approach to HIV that began a long time ago, and began in Western countries, not in African countries. Men who have sex with men are by no means the only group who have been blamed for HIV epidemics. Other groups include long distance drivers, sex workers, house girls, fishermen, miners, and many others. It’s this finger-pointing approach that gives rise to the stigma that those pointing the finger claim to abhor.

Thirty years into the HIV epidemic (I’m adopting the view that HIV is not a pandemic because most people don’t face any risk of being infected and prevalence is, and will remain, low in most countries) research institutions, NGOs, international bodies and, perhaps most importantly, donors are still obsessing about sexual behavior and pretending that HIV status is up to the individual when it is clear that a large, but as yet unestimated, proportion of infections is a result of unsafe healthcare and other skin-piercing processes.

UNAIDS’ Dubious Claims about HIV/AIDS 2013


UNAIDS risk missing their target of reducing “sexual transmission of HIV by 50% by 2015“. But there is a way of meeting that target, and they could meet it by tomorrow. If they belatedly admit that HIV is far more easily transmitted through unsafe healthcare, they could begin to estimate the contribution of things like reuse of needles, syringes and other equipment that comes into contact with blood and other bodily fluids.

This would also greatly assist their progress towards their ‘ZeroDiscrimination’ target too, because even though they can’t reverse the damage they have done by insisting that Africans are irremediably promiscuous, the status of this claim as institutionalized racism will eventually become clear, at least to those who are prepared to think the issue through a little (a surprisingly small number of people so far).

After all, reducing ‘sexual transmission’ is one of their stated goals, whereas UNAIDS has barely breathed a word about transmission through unsafe healthcare in their 20 year, multibillion dollar, celebrity studded reign. They could just quietly (imperceptibly, even) reveal some changes in the way figures are collected and next December 1, a re-estimation of non-sexual transmission of HIV could be the subject most deserving of their customary (spontaneous) standing ovation module.

UNAIDS are uncharacteristically frank about mass male circumcision, which is something of an embarrassing fiasco: “As of December 2012, 3.2 million African men had been circumcised […]. The cumulative number of men circumcised almost doubled in 2012, rising from 1.5 million as of December 2011. Still, it is clear that reaching the estimated target number of 20 million in 2015 will require a dramatic acceleration.” (They don’t say how many of the 3.2 million circumcised over quite a few years would have been circumcised anyway but took advantage of the free (anesthetized) operation.) Might this spell an unobtrusive retreat from this dangerous imperialist program?

But one of the heftiest pieces of bullshit in the ‘report’ (and there is stiff competition) is about “the goal of providing antiretroviral therapy to 15 million people by 2015”. They say that “As of December 2012, an estimated 9.7 million people in low- and middle-income countries were receiving antiretroviral therapy, an increase of 1.6 million over 2011. That brings the world nearly two-thirds of the way towards the 2015 target of 15 million people accessing antiretroviral treatment.”

The difference between UNAIDS’ claim and the truth is expressed in a few words, such as ‘were receiving’ therapy. If they said that 9.7 million people had been recruited on to a therapy program, that might have been true (or somewhat closer to the truth). But 9.7 million is, at best, the number of people who have at one time been put on a program. Neither UNAIDS, WHO, PEPFAR, CDC nor anyone else knows how many of those 9.7 million ever took the drugs, or for how long, how many dropped out of the program, how many were recruited on to two or more programs or simply died, etc.

No one knows, and no one really cares because 9.7 million is an impressive figure, and it sounds like a good attempt at the 15 million target. There is not much incentive to estimate how many people are alive and on antiretroviral treatment, indeed, such an estimate could prove fatal to several substantial institutions (not just UNAIDS, which seems to thrive on failure to achieve anything at all, aside from spending money and institutionalizing bigotry). Is the true figure 8 million people, 7 million, or some far lower number? Billions of dollars say that no one is going to ask this impertinent question (unless they are not in receipt of any of those billions, and never will be).

Unsafe healthcare does exist in extremely poor, high HIV prevalence countries, surprising as that may seem to those who are used to the mainstream view that HIV is hardly ever transmitted through heterosexual sex in every country in the world, but almost always transmitted through heterosexual sex in a handful of African countries. What contribution does unsafe healthcare make to the worst HIV epidemics in the world, all in sub-Saharan Africa? Would it be the one or two percent UNAIDS grudgingly suggests, or something far higher? We don’t know yet. No billions have been offered for the answer to this question.

Using cumulative figures is great, because you get that great ‘step’ effect when you produce bar graphs, and there is nothing like comforting, progressive steps to convince people that everything is good in UNAIDSland, and in the HIV industry in general. A very achievable 2015 target would be the abolition of UNAIDS and the promotion of safe healthcare. Because unsafe healthcare risks the spread of HIV, something UNAIDS has never got around to accepting. But I suspect that instead, there will be a continuation of the finger-pointing and victim-blaming that has characterized the mainstream approach to HIV in high prevalence countries so far.

More MDG Scapegoats: Industrial Disputes and Gay People


Another Millennium Development Goal (MDG) scapegoat. It sounds like bloody cheek to suggest that Kenya’s failure to reduce new HIV infections as quickly as predicted is a result of health personnel strikes. True, there have been strikes, but the country’s health services were decimated years ago by the strictures of international financial institutions and sheer neglect, and allowed to rot. Successive governments have also done an appalling job when it comes to industrial relations.

According to the article, Prevention of Mother to Child Transmission (PMTCT) coverage “fell by 20 percent in 2011-2012”, from 66% to 53%, representing 13,000 children newly infected with HIV. The 2015 target is close to 100% but, at 38%, Kenya seems unlikely to reach it, and the same could be said for most other African countries. However, there is nothing to back up the ridiculous claim that strikes played a significant part in such a massive fall in coverage.

The article does state that “Experts agree on the main reason behind the reduction in PMTCP – disruptions in the health services”, but that’s hardly a smoking gun. There have been numerous antiretroviral drug stockouts and other disruptions, for various reasons, and these may have a lot more to do with such a large drop in coverage.

Another possible problem in meeting the MDGs could be a transition process that PEPFAR funded programs have been going through. In South Africa it is estimated that “between 50,000 and 200,000 people may have fallen out of care in the transition”. Indeed, there are probably several reports available that would point to the reason for the fall in coverage, but journalists and politicians don’t seem to like reading reports.

Yes another article from Kenya has come up with an even more impertinent suggestion. It claims that there has been an ‘upsurge’ in gay sex, which is slowing the ‘war’ on HIV. The article suggests that Kenya has achieved a lot, with prevalence dropping from 7.2% to 5.6%. Perhaps they are expecting the next set of results to be less flattering.

Men who have sex with men face very high risk of being infected with HIV, and of transmitting it. But Kenya and most other African countries have refused to accept that this is a group that needs special attention, preferring to accept the HIV industry’s contention that most HIV transmission in African countries is a result of unsafe heterosexual sex. It sounds far more manly, doesn’t it.

Because transmission has decreased in some populations, the contribution of infections from men who have sex with men may look like it is increasing. But the claim that the country may not meet some of its MDGs because of an ‘upsurge in gay sex’ is as outrageous as the claim that industrial disputes are disrupting progress in reducing new HIV transmissions.

These are cheap shots at health personnel, gays and traditional birth attendants. But governments, NGOs, UNAIDS, donors and the lucrative HIV industry need all the help they can get when it comes to explaining why billions of dollars did not seem to result in particularly rapid declines in HIV transmission. There will be more to come.

Predicting the Millennium Development Goal Scapegoats


Come 2015 a lot of people will still be flailing about looking for scapegoats to explain their country’s falling short of various Millennium Development Goals. But one group of scapegoats must be well accustomed to having the finger pointed at them; traditional birth attendants (TBA). In an article from Uganda appearing on AllAfrica.com, TBAs are being “blamed for HIV among newborn babies”.

Is the finger of blame being pointed at them on the basis of research this time, or is it the usual politico/journalistic reflex? The sheer vagueness of the article suggests that it is based on the latter. What self-respecting politician or journalist would read research, anyhow? No checkable source is cited, though that’s nothing unusual for AllAfrica.com; and one of the people cited says “there are many deaths and new HIV infections among new babies that go undocumented and […] the statistics may be falling short of the exact number”.

If some of the new infections among babies are documented, why are they not also investigated? Are the mothers HIV positive? Or are some of the mothers HIV negative? HIV negative mothers with HIV positive babies are not uncommon, but investigations into this phenomenon in African countries is very rare indeed.

An obvious question for politicians, journalists and others who wish to indulge in the perennial practice of blaming people, whether they be TBAs, men who have sex with men, women, foreigners, truckers or whoever else, is why HIV prevalence tends to be a lot higher in areas where people have better access to health facilities. TBAs tend to be more common in isolated and rural areas, where HIV prevalence is generally a lot lower.

The suggestion is that TBAs are not able to protect babies of HIV positive mothers from being infected, whereas qualified health personnel may be able to prvent mother to child transmission. True as this may be, how are TBAs supposed to be able to resolve this problem themselves? If it is the case that about half of all deliveries are overseen by TBAs, rather than conventional health personnel, this is hardly the fault of TBAs. They are not drawing big salaries, nor are they receiving thorough training or any other incentives for their work.

There are severe shortages of skilled health personnel in Ugandan health facilities. The facilities are stretched beyond their limits already. Is the government going to import enough doctors, nurses and others to fill the 50-60% shortfall that many facilities are experiencing? And more importantly, if the health facilities are going to be even more oversubscribed than they currently are, how safe will they be then? They are not currently safe places to give birth and some health figures show that those attending health facilities could be at higher risk of being infected with HIV.

Before blaming TBAs, it would be a good idea to carry out some research to find out exactly how so many babies are being infected with HIV, and how many have HIV negative mothers. Once that is clear, Uganda will be in a position to figure out what to do next, though it remains to be seen whether the country will be provided with the means to do anything effective. Donors are often keen on providing various health services for high profile, newsworthy conditions, but they are a lot less enthusiastic when it comes to ensuring that health services are safe.

Justine Sacco: Dangerous Truths and Dangerous Falsehoods about HIV


An American on her way to South Africa is said to have Tweeted “Going to Africa. Hope I don’t get AIDS. Just kidding. I’m white!” This is a heartless and insensitive remark to make. But what makes it most heartless and insensitive for a white American to say it is the fact that it is so true. In the US, African Americans accounted for 44% of all new HIV infections in 2010, despite representing only 12-14% of the population. Also in the US, men who have sex with men are said to represent about 4% of the population, but account for 63% of all new HIV infections in 2010, and a disproportionate number of them are black/African American.

Even in South Africa HIV prevalence among white people is very low. But national prevalence is amongst the highest in the world and there are more HIV positive people in South Africa than in any other country. While America has the worst HIV epidemic in the developed world, with over 1.1 million HIV positive people, the majority of infections arise among men who have sex with men and (to a lesser extent) intravenous drug users. HIV infection among white heterosexuals who have no serious risks, such as receptive anal sex or intravenous drug use, is very low.

The American who tweeted the first stupid, but sadly true, remark offended so many people that she arrived in South Africa to find that a storm had erupted on Twitter and she had lost her job. So, to make matters worse, she made a statement to a South African newspaper which contained a dangerous but often heard falsehood:

“For being insensitive to this crisis — which does not discriminate by race, gender or sexual orientation, but which terrifies us all uniformly — and to the millions of people living with the virus, I am ashamed.”

This is completely untrue, as the figures for the US show so clearly. About two thirds of people living with HIV globally are black Africans. An estimated 60% of HIV positive people in Africa are female, compared to only 20% of new infections in the US in 2010. Hispanics and Latinos in the US made up 21% of new infections in 2010; the rate of infection was 2.9 times higher in Latinos than it was in white males; it was also 4.2 times higher in Latinas than in white women.

HIV most definitely does discriminate by race, gender and sexual orientation. This is not a new discovery, either. It may be an acceptable thing to say in certain circles, but we should never forget the differences between HIV in Africa, where the majority of HIV positive people live, and HIV in developed countries, where HIV is less prevalent overall, and is rare among heterosexuals who have no serious risk behaviors.

Justine Sacco, who tweeted the remark, is so right to think that she is very unlikely to be infected with HIV; a lot less likely than a black African, and also less likely than a black or Latino/Latina American. It is disturbing to think that so many people continue to believe or say otherwise. Why is HIV prevalence so high among black Africans and black/African Americans, yet comparatively low among white people, especially white men who engage in no serious risk behaviors?

Happy New Year to All our Visitors


In our first two full years online the Don’t Get Stuck With HIV website and blog has received 48,000 page views, over 31,000 of them in 2013. The number of monthly views has increased to a high of 3,600 in December 2013 and the daily average has reached 116 views in the same month.

With over 7,000 views, our Blood-borne Risks page (‘Estimated risks to transmit HIV through various skin-piercing events’) was the most popular, followed by the home page, at 6,000 views. Sexual transmission risks, our pages about dental care, tattooing, hairstyling (etc), bloodtests and injections all received over 1,000 views each.

Also, a couple of blog posts were very popular, especially ‘Have we ignored a very simple procedure that could significantly reduce the risk of sexual transmission of HIV to men from women?‘ (nearly 2,000 views) and ‘Denied, withheld, and uncollected evidence and unethical research cloud what really happened during three key trials of circumcision to protect men‘ (1,600 views). A post on genital hygiene also received almost 1,000 views.

An analysis of about 4,000 search queries, comprising about 500 search terms, revealed that searches about syringes, other medical instruments and their uses accounted for about one quarter of all queries. Tattoos, dental care, manicures and pedicures and HIV transmission risk accounted for another 1,300 queries. About 260 searches were about circumcision if you add in searches for ‘Prepex‘, which is a fairly popular subject.

We have had visitors from 177 different countries, although we only 10 or fewer page views from 64 of those countries. With nearly 20,000 views from the US since February 2012, no other country comes close, although nearly 5,000 have been from the UK. India, Canada and Australia have accounted for another 7,000 views.The highest number of views from an African country was 864, from South Africa.

Our top referrer, accounting for over 30,000 views, was Google, mostly Google.com; about 3,000 were from Google.co.uk. Facebook, Reddit, Twitter and a few other tools account for a few hundred views each, although stimulating referrals from Facebook and Twitter required a disproportionate amount of work.

We thank visitors for viewing our site and blogs. We hope you found what you were looking for. We welcome comments and feedback and are grateful for what we have received so far. Using the above data, we intend expanding and reorganizing Don’t Get Stuck With HIV over the next year and hope we keep expanding.

All the best for 2014!

Using Bad Data to Obscure Deadly Errors


In an article published in early December 2012, Jacques Pepin and colleagues reported that less than 1 in 20 Africans received an unsafe injection in 2010.[1] According to them, this was a huge improvement from the situation in 2000, when more than 1 in 3 got an unsafe injection.

The story sounds good, but let’s put it into context.

First, these rosy estimates distract from facts that need answers. Why do 16%-31% of HIV-positive children in Mozambique, Swaziland, and Uganda, have HIV-negative mothers (among children with tested mothers; see: https://dontgetstuck.wordpress.com/cases-unexpected-hiv-infections/). Why do so many mutually monogamous couples find that one or both partners are HIV-positive?

Second, the authors accept a double standard. In countries that fund health aid programs in Africa, governments respond to recognized reuse of unsterile instruments in health care with investigations to see if patients have been harmed. For example, after authorities in New Zealand found that a clinic had reused unsterilized instruments, governments of New Zealand and Australia issued a public notice warning people who had attended the clinic during 2010-12 that they might have been exposed to hepatitis B, C, or HIV and inviting them to come for tests.[2] But if the clinic with recognized unsafe procedures is in Africa, the response is entirely different. In Africa, people who present themselves as concerned and knowledgeable about health care safety, such as Pepin and colleagues, estimate that percentages of procedures are unsafe without asking for investigations. Such bland acceptance of deadly errors endorses a double standard.

Third, what Pepin and others state as facts are weak estimates based on unreliable data. Most of their data for 2010 comes from national surveys that asked people – in the midst of several hours of questions[3] about diet, education, birth control, sexual behavior, and blah, blah, blah – how many injections they had in the last year and whether the syringe and needle for the last injection came from a sealed pack. In a long survey, people are not able to take time to think and remember. Even with time to think, it’s hard to remember numbers of injections over the past year. Consider: A survey in India asked people if they had received an injection in the last 2 weeks and if they had received an injection in the last 3 months. The estimated number of injections per person per year was 5.9 based on 2 week recall, but only 2.9 based on 3 month recall.[4]

A bad manager listens to sycophants who tell him soothing fantasies that encourage him to ignore uncomfortable facts. I expect there will be many bad managers in health aid organizations and in African ministries of health who will be only too ready to cite Pepin and colleagues’ soothing fantasies rather than to do the right thing – to trace and investigate sources of HIV infection. Pepin and colleagues are not alone. For decades, sycophants who can cobble together weak evidence and arguments to say Africans only rarely get HIV from health care have gotten more attention than so many HIV-positive children with HIV-negative mothers.


 

[1] Pepin J, Abou Chakra CN, Pepin E, Nault V (2013) Evolution of the Global Use of Unsafe Medical Injections, 2000–2010. PLoS ONE 8(12): e80948.

doi:10.1371/journal.pone.0080948. Available at: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3851995/pdf/pone.0080948.pdf (accessed 22 December 2013).

[2] NZers warned over HIV at Sydney clinic. New Zealand: NZCity, 16 December 2013. Available at: http://tinyurl.com/l34v4ab (accessed 22 December 2013).

[3] ICF International. Demographic and Health Surveys Methodology: Questionnaires: Household, Woman’s, and Man’s. Calverton, Maryland: ICF International, 2011. Available at: http://www.measuredhs.com/pubs/pdf/DHSQ6/DHS6_Questionnaires_5Nov2012_DHSQ6.pdf (accessed 23 December 2013).

[4] See Table II in: Arora N K, et al. Assessment of Injection Practices in India, Executive Summary. New Delhi: InClen Trust, 2005. Available at: http://www.inclentrust.org/uploadedbyfck/file/complete%20Project/Executive%20summaru/15_Main%20Report%20Book%20(29-6-06)%20only.pdf (accessed 22 December 2013).

Risk compensation after male circumcision


jimgthornton's avatarRipe-tomato.org

Conclusion contradicts data

This qualitative study of 28 recently circumcised Kenyan men, and another 18 awaiting circumcision, appeared in Health Education Research last week (click here).

As the authors admit, the design was inappropriate, and the samples too small and unrepresentative, to measure the rate of anything so, correctly for a qualitative study, they reported no numbers. Instead their aim was to tease out the existence of beliefs and behaviours which might have been missed in larger surveys, using in depth interviews and representative quotations. They were interested in whether men realised that circumcision only provided partial protection against HIV infection, and whether they were likely to increase sexually risky behaviour as a result.

For the first question it turned out that all respondents knew that circumcision provided only partial protection against HIV transmission. The authors concluded accurately that “Participants demonstrated good understanding of partial protection”.  

But when they turned to…

View original post 373 more words

Do medical researchers in Africa protect babies? Maybe not always


[Note: For more information, see Jim Thornton’s 11 October blog on “Boston/Botswana circ. trial update,” available at: http://ripe-tomato.org/2013/10/11/bostonbotswana-circ-trial-update/]

As part of medical research to find the best technique to circumcise new-born boys in Africa, a doctor in Botswana circumcised 300 babies 2-11 days old during 2009-10. The US government paid for the research, and a doctor from Brigham and Women’s Hospital in Boston managed the research [reference 1, below].

Three of the 300 babies died within 4 months after being circumcised [reference 2]. There is no controversy about two of the deaths: one baby died after “prolonged coughing and diarrhea” more than 10 weeks after being circumcised; a second died of gastroenteritis 25 days after circumcision [3].

However, one baby’s death raises questions. The day after being circumcised, the baby was brought to the local health center with fever and difficulty breathing, and was then transferred to the district hospital. He died that day – only 3 days old and 1 day after being circumcised. The research staff did not learn of his hospital admission or death until the next day [3].

Did the circumcision contribute to his death? Without reporting any information from blood or other tests or any observation of the infant’s circumcision wound, the study team in April 2013 reported the baby “died of neonatal sepsis on his second [3rd?] day of life, with the death reviewed by the study Data Safety and Monitoring Committee, Botswana Health Research and Development Committee, and Brigham and Women’s Hospital Institutional Review Board and not thought to be procedure related” [emphasis added; from pp e133-134 of reference 1].

So, with stout denials but minimal information, the question is still there: Did the circumcision contribute to the baby’s death?

Here’s an expert opinion by Dr Jim Thornton, former editor of the British Journal of Obstetrics and Gynecology (quoted from: http://ripe-tomato.org/2013/10/11/bostonbotswana-circ-trial-update/): “A healthy term baby dies 24 hours after a research operation and no tests nor autopsy are done. However the researchers, their own DSMC [Data Safety Monitoring Committee], and the two IRB’s [Institutional Review Boards] who had approved the research all conclude ‘that it was extremely unlikely that the baby’s death was related to the circumcision procedure’! Am I going mad? ‘Extremely unlikely’! How can any sane doctor possibly conclude that?”

Medical researchers are ethically and legally responsible to protect research participants. Because the study was funded by the US government, US laws apply. The research team did not report adequate information to support their claim the death was unrelated to the circumcision. Without convincing evidence the death was not related, it should have been reported as possibly related, as required by US regulations (see section b in this link: http://www.hhs.gov/ohrp/policy/advevntguid.html#Q2; see also regulation 45 CFR 46.103(b)(5) in this link: http://www.gpo.gov/fdsys/pkg/CFR-2011-title45-vol1/pdf/CFR-2011-title45-vol1-sec46-103.pdf ). Accepting the possibility the circumcision was at least partially responsible for the baby’s death, the researchers should have reported the death as an adverse event and compensated the parents for the death of their child.

Because the death was not adequately explained, because researchers’ denied responsibility with insufficient evidence, and because the Institutional Review Board at Brigham and Women’s Hospital’s did not insist that researchers adequately explain the death and/or acknowledge the possibility the death may have been related to the research, the US government’s Office for Human Research Protections should investigate the death, the management of the research project, and the conduct of the Institutional Review Board.

On 18 July 2013, eight doctors disturbed by the baby’s death wrote to the US Office of Human Research Protections asking for an investigation and complaining that the Institutional Review Board’s “monitoring of adverse events [ie, the 3rd baby’s death] was inadequate.” The doctors stated: “In our opinion the conclusion that ‘it was extremely unlikely that the baby’s death was related to the circumcision procedures’ is irrational. This was a healthy newborn baby. The death occurred 24 hours post procedure. No investigations were done… We believe that the IRB [Institutional Review Board] had ceased to protect the research participants, and was protecting the researchers from criticism” (quoted from their letter, available at: http://ripetomato2uk.files.wordpress.com/2013/10/allegation-to-ohrpe.pdf (accessed 24 October 2013).

Overlooking the unexplained death, the research team concluded: circumcising babies “can be performed safely in Botswana”[quoted from p e136, reference 2]. That conclusion is doubtful. Here’s an unintended conclusion from the research: If you agree to be a participant in medical research funded by the US government in Africa, you might not be protected by US regulations. Here’s another unintended conclusion: You probably shouldn’t believe everything you read about the safety of circumcision in health care settings in Africa.

References

1. Plank RM. Infant male circumcision in Gaborone, Botswana, and surrounding areas: feasibility, safety, and acceptability. Study record, trial NCT00971958. Available at:  http://clinicaltrials.gov/show/NCT00971958 (accessed 26 October 2013).

2. Plank RM, Ndubuka NO, Wirth KE, et al. A randomized trial of Mogen Clamp versus Plastibell for neonatal male circumcision in Botswana. J Acquir Immune Defic Syndr. 2013: 62: e131-e137. Available for free download at: http://journals.lww.com/jaids/Fulltext/2013/04150/A_Randomized_Trial_of_Mogen_Clamp_Versus.14.aspx (accessed 24 October 2013).

3. Plank RM. Author’s Reply: A Randomized Trial of Mogen Clamp Versus Plastibell for Neonatal Male Circumcision in Botswana. J Acquir Immune Defic Syndr. 2013; 64: e13-e14. Available for free download at: http://journals.lww.com/jaids/Fulltext/2013/10010/Author_s_Reply___A_Randomized_Trial_of_Mogen_Clamp.20.aspx (accessed 24 October 2013).